Courses

A critical discussion of scientific production in teacher development.
COD Workload Description
73307-02 30 The course will address the revision of scientific articles and a their critical analysis in teacher development, in view of the following criteria: Relevance for research in the area; The methodology proposed for response to research questions; The justification for conclusions in the findings; The relevance for discussion and acknowledgment of the limitations and possibilities of study;
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Advanced Analysis of Qualitative Data
COD Workload Description
313A8-02 30 This course addresses: Approaches, methods and techniques for qualitative research in Psychology; The main theoretical-methodological currents that support qualitative analyses in human sciences investigations; Research methods and procedures for the collection and analysis of different types of research employing the qualitative method.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Education Master's Not required
Education Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Ethics and Political Philosophy Master's Not required
Ethics and Political Philosophy Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Metaphysics and Epistemology Master's Not required
Metaphysics and Epistemology Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Master's Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Education theories and cultures Seeks to explore the relationship between anthropology, history, philosophy, sociology and education, by discussing political and cultural conditions in education. It brings together theoretical and empirical theories and research, so improving our understanding of the diversity of the human experience in the different processes of development.
People and education It studies education as a process that involves the person's non-development, training and self-training, highlighting its intertwining as health and well-being. It hosts interdisciplinary studies and research that enhance the pedagogical dimension of human experience in its interactions as biological, psychosocial, biographical, cultural aspects of two subjects and subjectivities in contemporary society.
Education training, policies and practices Seeks to explore educational processes in different training settings, from socio-political, historical and cultural perspectives, aiming at a critical analysis of policies, training practices, and educational planning in different contexts. It scrutinizes pedagogical practices in several degrees and types of education, enabling insights for decision making regarding changes in society and in the educational process.
Education in Science and Mathematics (ESM) Studies teaching and learning in Science and Mathematics in different training spaces, using theoretical and methodological contributions related to education through research; epistemologically linked to the domain of language, to inter and transdisciplinarity – to science and the nature of being and to the modeling processes in Science and Mathematics, associated with initial and continuing teacher training, in Basic Education and Higher Education. It covers research involving scientific and technological development, scientific literacy and the popularization of Science and Mathematics in formal and non-formal spaces of education.
The State and Theories of Justice This line of research addresses the theoretical and pragmatic aspects of the theories of justice from scholars such as Immanuel Kant, John Rawls and Jürgen Habermas, as well as their different critical and alternative views in communitarian and utilitarian theories.
Ethics Principles This line of research addresses the central issues of Ethics as they have been conceived over time and under the systematic aspect, in view of scholars such as Plato, Aristotle, Kant and others. The relationship between practical and theoretical reason is a central area.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Phenomenology and Hermeneutics This line of research is intended to analyze the classical theories of knowledge under the perspective of the philosophers of phenomenology, which has been the norm in Europe for almost a century and has representatives all over the world.
Philosophy in the Middle Ages This line of research addresses philosophers of the Middle Ages.
Analytic Epistemology This line of research addresses the fundamental topics of contemporary Epistemology: theories of knowledge, theories of epistemic rationality, skepticism and epistemic paradoxes.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Assessment Methodology in Research
COD Workload Description
63339-02 30 Understanding the basic concepts of biostatistics is basicl for the planning, collection, evaluation and interpretation of data obtained in health research. Thus, this course aims to equip students to describe and perform basic analysis and present research data.
Professors Home time Lattes
THIAGO WENDT VIOLA 4 years and 4 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Required
Pediatrics Inter-institutional doctorate degree Required
Pediatrics Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
BIOCHEMISTRY OF PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES
COD Workload Description
73164-02 30 This course will address the study of the structure and operation of the main biological compounds in the context of physiological and pathological processes.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
BIOETHICS IN DENTISTRY
COD Workload Description
83274-02 30 The objective of this course is to provide a systematic study of relevant themes or issues, as well as the ethical dilemmas that emerge from the theoretical and practical field of Biomedical Sciences.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biology and Orofacial Rehabilitation Master's Not required
Biology and Orofacial Rehabilitation Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Ontological Clinic Master's Not required
Ontological Clinic Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
oral biology Master's Not required
oral biology Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Etiopathogenesis and Treatment of Periodontal and Periapical Diseases This line of research aims to study the mechanisms involved in periapical and periodontal alterations, aiming to analyze their relationship with systemic diseases, as well as to identify new treatment strategies for these conditions.
Etiopathogenesis and Treatment in Stomatology The objectives of this line of research involve the evaluation of the pathophysiology of diseases affecting the oral mucosa and salivary glands, including oral cancer, focusing on the clinical, immunological, and pathological aspects of these conditions, in order to identify new forms of prevention and treatment of such diseases.
Pediatric Oral Health This line of research aims to evaluate new approaches to the prevention, diagnosis, and treatment of oral cavity disorders, focusing on the management of pediatric patients.
Restorative and Reconstructive Dentistry This line of research focuses on developing new technologies and approaches aimed at aesthetic and functional oral rehabilitation, using laboratory and clinical assessment methodologies. It also includes new approaches for the orthodontic, orthopedic, and surgical correction of orofacial deformities, seeking to improve the diagnosis and management of patients with these conditions.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Biomechanics, Pain and Orofacial Dysfunction This line of research is aimed to analyze the pathophysiology of orofacial pain, temporomandibular dysfunction, bruxism and parafunctional habits, focusing on the biomechanical characterization of the stomatognathic system and its reflexes on the organism, seeking to identify new diagnostic and therapeutic strategies for these conditions.
Biomaterials and Tissue Engineering This line of research aims at the development and evaluation of the efficacy and safety of new dental materials, as well as innovative tissue engineering strategies, focusing on tissue regeneration and the reduction of infectious oral complications.
Microbiology and Oral Immunology This line of research aims to develop research with a specific focus on oral microbiology and oral immunology, for diagnostic and therapeutic purposes.
Basic Cardiology and Research
COD Workload Description
33335-02 30 This course will address the analysis, introduction and discussion of the main clinical studies in the lines of research under the area of cardiology, which will provide students with continuous training in popular therapies, with emphasis on evidence-based cardiology.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Basic Immunology and Research
COD Workload Description
33326-02 30 This course is generally intended to provide students with basic insights into Immunology and deeper ones into the major improvements in the area of Clinical Immunology over the latest years. Students will ultimately be able to understand both the fundamental determinant immunological processes of defense of normal individuals and the phenomena of inflammation and self-immunity, as well as to recognize the associations between diseases and genetic background, especially when it comes to the human histocompatibility system. Students will be able to fully and clearly understand an article on Immunology.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Basic Pharmacology
COD Workload Description
63379-01 0 To follow are the topics this course will address: basic concepts in molecular mechanisms of the drug-target interaction, with emphasis on drugs that modulate the intracellular signaling and cellular responses; Structure and function of receptors, signal transduction pathways; Discussion of scientific articles on drugs that operate in cellular signaling pathways.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Biochemical and Molecular Pharmacology Seminar
COD Workload Description
63380-02 30 This course will address the main biochemical and molecular mechanisms involved in the action of drugs. To follow are some topics of interest: (1) study of mediators and biochemical and molecular aspects of pharmacological receptors: G protein-coupled receptors; receptor tyrosine kinase; nuclear receptors; ion channels; enzymes; transporters, among others; (2) molecular biology methods: receptor cloning, transgenesis, knockout, knockdown, heterologous transfection, site-directed mutagenesis; (3) main signaling routes and components of the intracellular transduction systems; (4) study of the mechanisms of action of main drugs used in current pharmacotherapy.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Bioethics
COD Workload Description
33329-02 30 This course aims to reflect about life and living in the area of health activities from the perspective of Complex Bioethics. Issues related to clinical activities carried out in the field of Medicine and other health related areas will be discussed, involving: professional-patient relationship; privacy and confidentiality; informed consent process; beginning and end of life, including palliative care; organ transplants and blood transfusion; allocation of resources in the health area.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Required
Biochemical and Molecular Pharmacology Doctorate Required
Medical Practice Master's Required
Medical Practice Doctorate Required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Required
Neurosciences Doctorate Required
Surgical Practice Master's Required
Surgical Practice Doctorate Required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Biology of Aging
COD Workload Description
40504-04 60 The topics that will be addressed in this course are: Study of biological phenomena involved in the aging process of living beings; An analysis of the different theories intended to explain aging and the endogenous and exogenous factors affecting this process; Mechanisms for replicative senescence: stochastic mechanisms, signal transduction and regulation of cell proliferation, genetic mechanisms; Experimental models for the study of aging; Genetic factors involved in the process of senescence; Cellular and molecular mechanisms of immunosenescence; Immunological risk; Premature immune aging; Modulation of immunosenescence.
Professors Home time Lattes
MOISES EVANDRO BAUER 24 years and 11 months Link
DENISE CANTARELLI MACHADO 26 years and 11 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Required
Biomedical Gerontology Doctorate Required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Cellular models and tools for in vitro studies
COD Workload Description
1931C-02 30 The fast evolution of medical technology and new conceptual thinking in the field of biology has increased the need for health professional specialization in the field of cell and molecular biology. The study of cellular and molecular medicine is often referred to as the "medicine of tomorrow". This innovative line of medicine aims to provide an understanding of how normal cellular processes are altered, failed or destroyed by environmental insults or illnesses, presenting tools for available not only to compose the translational "bench-to-bedside" but also meet the demand for clinical questions returning understanding and therapeutic guidance from molecular and cellular bases. The mapping of the human genome and the rise of induced pluripotent stem cells (iPSC) were paradigm breaks in the history of modern medicine. Advanced technologies such as high throughput analysis (sequencing, microarray and proteomics), selective gene silencing and the use of cell models such as lineages, primary culture and iPSC allow us to understand the mechanisms of genes, proteins and signaling pathways involved in the formation or progression of diseases, providing a totally new understanding base of biological systems and generating possible hypotheses for understanding different pathologies, besides the possibility of generating platforms for tests of new therapeutic alternatives.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Chemotherapeutic Agents and Mechanisms of Action
COD Workload Description
33327-02 30 This course will address the mechanisms of action of chemotherapeutic agents and their molecular targets as well as the mechanisms that result in their resistance. The experimental strategies that allow for the determination of kinetic, chemical and enzymatic mechanisms of molecular targets will be described. Additionally, the mechanisms of action of reversible inhibitors (including slow-onset inhibitors) will be looked at as well as virtual screening of ligands. This course will enable an understanding of the rational design of drugs based on the mode of inhibitive action of chemical compounds (chemotherapeutic ones).
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Chest Imaging Seminars
COD Workload Description
1939R-02 30 The University of Florida Chest Imaging Seminar Series present a comprehensive set of educational lectures and interactive case discussions, covering important and timely topics in chest imaging, including HRCT and diffuse lung disease, airway disease, lung infection, mediastinal masses, lung nodule diagnosis, lung cancer screening, and state of the art diagnosis of cardiovascular diseases. Emphasis will be placed on interaction with the audience with ample time for questions and discussion. The course is based in 20 image enriched lectures with an additional 100 cases and suggested review papers for open discussion. The lectures will be at 12:00 - 13:00 and will be presented live and transmitted by Zoom.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Critical Evaluation of Research Projects
COD Workload Description
7331G-02 30 The topics this course addresses are as follows: The scientific method in the process of development of researchers and professors; Analysis of the hypothesis and of the development of the topics to be researched; Critical analysis of the development of the thesis or dissertation; Presentation and discussion of research projects with peers and professors.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Critical Evaluation of Research Projects II
COD Workload Description
7333B-02 30 The topics this course addresses are as follows: The scientific method in faculty and researcher development. Analysis of the hypothesis and of the development of the topics to be researched. Critical analysis of the development of the thesis or dissertation. Presentation and discussion of research projects with peers and professors.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
DENTAL BIOSTATISTICS
COD Workload Description
83293-02 30 The purpose of this course is to introduce the essential aspects of statistics and their applications in dental research. It will promote the understanding of the elements of statistical inference and to help identify and choose the main basic statistical procedures that occur in practice. It will also present the justification for the calculation of sample size in different dental research situations.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biology and Orofacial Rehabilitation Master's Not required
Biology and Orofacial Rehabilitation Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Ontological Clinic Master's Not required
Ontological Clinic Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
oral biology Master's Not required
oral biology Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Etiopathogenesis and Treatment of Periodontal and Periapical Diseases This line of research aims to study the mechanisms involved in periapical and periodontal alterations, aiming to analyze their relationship with systemic diseases, as well as to identify new treatment strategies for these conditions.
Etiopathogenesis and Treatment in Stomatology The objectives of this line of research involve the evaluation of the pathophysiology of diseases affecting the oral mucosa and salivary glands, including oral cancer, focusing on the clinical, immunological, and pathological aspects of these conditions, in order to identify new forms of prevention and treatment of such diseases.
Pediatric Oral Health This line of research aims to evaluate new approaches to the prevention, diagnosis, and treatment of oral cavity disorders, focusing on the management of pediatric patients.
Restorative and Reconstructive Dentistry This line of research focuses on developing new technologies and approaches aimed at aesthetic and functional oral rehabilitation, using laboratory and clinical assessment methodologies. It also includes new approaches for the orthodontic, orthopedic, and surgical correction of orofacial deformities, seeking to improve the diagnosis and management of patients with these conditions.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Biomechanics, Pain and Orofacial Dysfunction This line of research is aimed to analyze the pathophysiology of orofacial pain, temporomandibular dysfunction, bruxism and parafunctional habits, focusing on the biomechanical characterization of the stomatognathic system and its reflexes on the organism, seeking to identify new diagnostic and therapeutic strategies for these conditions.
Biomaterials and Tissue Engineering This line of research aims at the development and evaluation of the efficacy and safety of new dental materials, as well as innovative tissue engineering strategies, focusing on tissue regeneration and the reduction of infectious oral complications.
Microbiology and Oral Immunology This line of research aims to develop research with a specific focus on oral microbiology and oral immunology, for diagnostic and therapeutic purposes.
DENTAL EPIDEMIOLOGY
COD Workload Description
83292-02 30 This course covers the basic principles of epidemiology, identifying the biosocial indicators of the health-disease processes of cavities and periodontal disease, seeking to identify the existing connections related to them. The specific objectives are:
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biology and Orofacial Rehabilitation Master's Not required
Biology and Orofacial Rehabilitation Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Ontological Clinic Master's Not required
Ontological Clinic Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
oral biology Master's Not required
oral biology Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Etiopathogenesis and Treatment of Periodontal and Periapical Diseases This line of research aims to study the mechanisms involved in periapical and periodontal alterations, aiming to analyze their relationship with systemic diseases, as well as to identify new treatment strategies for these conditions.
Etiopathogenesis and Treatment in Stomatology The objectives of this line of research involve the evaluation of the pathophysiology of diseases affecting the oral mucosa and salivary glands, including oral cancer, focusing on the clinical, immunological, and pathological aspects of these conditions, in order to identify new forms of prevention and treatment of such diseases.
Pediatric Oral Health This line of research aims to evaluate new approaches to the prevention, diagnosis, and treatment of oral cavity disorders, focusing on the management of pediatric patients.
Restorative and Reconstructive Dentistry This line of research focuses on developing new technologies and approaches aimed at aesthetic and functional oral rehabilitation, using laboratory and clinical assessment methodologies. It also includes new approaches for the orthodontic, orthopedic, and surgical correction of orofacial deformities, seeking to improve the diagnosis and management of patients with these conditions.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Biomechanics, Pain and Orofacial Dysfunction This line of research is aimed to analyze the pathophysiology of orofacial pain, temporomandibular dysfunction, bruxism and parafunctional habits, focusing on the biomechanical characterization of the stomatognathic system and its reflexes on the organism, seeking to identify new diagnostic and therapeutic strategies for these conditions.
Biomaterials and Tissue Engineering This line of research aims at the development and evaluation of the efficacy and safety of new dental materials, as well as innovative tissue engineering strategies, focusing on tissue regeneration and the reduction of infectious oral complications.
Microbiology and Oral Immunology This line of research aims to develop research with a specific focus on oral microbiology and oral immunology, for diagnostic and therapeutic purposes.
Digital Technology and Imaging Analysis in Health Sciences
COD Workload Description
73308-02 30 This course is intended to introduce students to the basic concepts of IT applied to medicine, specially concerning medical imaging, as well as to provide fresher insights into the more commonly used equipment, such as: videocameras, digital cameras and other devices attached to different pieces of equipment, such as microscopes and endoscopes.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Effectively Communicating Research
COD Workload Description
7331E-02 30 Communication and leadership are essential parts of your research and a crucial component for a successful career as a researcher. This class creates learning opportunity for students who are in the process of writing for publication or creating communication materials for scientific oral or poster presentations.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
English article writing
COD Workload Description
1932B-02 30 Scientific development is a continuous and systematic process of actions aimed at contributing to academic excellence, based on teaching and research. The production of knowledge alone is not enough to consolidate the qualification of graduate students. Dissemination of knowledge is required for the scientific community and society as a whole. The dissemination of new knowledge acquired at our University and the sharing of knowledge globally can only be intensified when they are disseminated in a common peer language, facilitating interaction between teaching and research institutions from different countries. Today, internationalization is mandatory for continued development and scientific recognition. To this end, our graduate students will be required to receive English language training in the dissemination of their productions to the scientific community in international journals, as expected for the excellent graduate programs.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Epidemiological Method Practice
COD Workload Description
20500-02 30 The course aims at fostering a critical reflection on the scientific method and its practical use in research. It will address, in a practical way, the concepts of clinical epidemiology and biostatistics by means of their application in research projects developed by graduate students. It will enable the discussion of all elements of a research project, with emphasis on the methods used by each student in their research project.
Professors Home time Lattes
CARLA HELENA AUGUSTIN SCHWANKE 22 years and 4 months Link
REGIS GEMERASCA MESTRINER 13 years and 4 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Ethics
COD Workload Description
23392-02 30 Ethics is one of the most important areas of philosophical thought and has become increasingly important in view of the wide variety of serious issues human beings face today. The course is primarily intended to address the fundamental importance of Ethics within the areas of philosophy, science and humanities in general and then, study historically referenced models of understanding of ethics in its most relevant aspects, under a contemporary look, by discussing important points and paving the way for a more mature approach of important ethical issues, not only in philosophical terms, but in terms of diverse academic interests which shape the health care professionals' concerns today. This course intends to provide students with a consistent introduction to contemporary conditions of understanding of major ethics issues, which may even facilitate the access of structures of understanding of traditional ethical and historical issues over the history of philosophy and then pave the way for the course of Bioethics in its several ramifications and variables, rather than provide a mere list of historical models of approach to ethical issues, even though those classical references will not be overlooked.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Evidencia Clínico-Epidemiológica
COD Workload Description
7331F-02 30 Las recomendaciones clínicas engloban um análisis entre los benefícios y las desventajas (riesgos, costos, desconforto) de una determinada intervención. Para adaptar las recomendaciones al ámbito de la investigación y de la clínica, el profesional del área de la salud debe considerar las evidencias actuales y su evaluación subyacente. Um abordaje sistemático que considere la graduación y evaluación de la cualidad de las evidencias puede contribuir de manera efectiva con la práctica de la investigación y de la clínica.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Experimental Surgery
COD Workload Description
23399-02 30 This course will address the analysis, development and the execution of experimental protocols in the area of surgery and clinical studies.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Fundamentals of Medical Imaging Technologies: An Interdisciplinary Approach
COD Workload Description
1932C-03 45 The course will provide a comprehensive overview of the most relevant diagnostic imaging modalities used in radiology and nuclear medicine, covering both clinical and technical aspects, throughout an interdisciplinary approach. The course will introduce the physical principles underlying different medical imaging modalities along with examples of specific applications. The basic principles of digital image processing, including common terminology and the components that define image quality will be discussed. The ongoing research and new developments in molecular and hybrid imaging modalities will be discussed.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Health of vulnerable populations: biopsychosocial determinants and particularities in care.
COD Workload Description
193BK-01 15 The biopsychosocial determinants and particularities of health care for vulnerable populations will be discussed. Initially, the vulnerability context will be defined, allowing the identification of the main vulnerable populations. Among them, people with mental illness, people with physical disabilities, populations deprived of liberty, people living with HIV, people with albinism, traditional communities, people in rural contexts, sex and gender minorities, cis women, the elderly, populations in street and black population. At this point, intersectionality bias will be used to explore the interaction between vulnerable social factors. Seminars will be held with discussion of key studies and classic texts deepening the particularities of health care for sex and gender minorities, cis women, the elderly, homeless populations and the black population
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
How to get funding for health research?
COD Workload Description
193BE-01 15 Improve the development of your proposals for research funding by building successful and competitive proposals. This course offers a comprehensive approach to developing proposals for submission to foundations and private/governmental entities. burnout. It is expected that the student will be able, with this training, to improve their writing and planning skills, in order to increase their chances of raising research funding in the health area.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Integrity and Ethics on Research
COD Workload Description
19302-02 30 Nowadays, with the free access to knowledge and data through social networks and the Internet, the number of cases of misconduct in research execution and publication around the world is increasing, leading to the loss of the credibility of scientific publications. This course aims to guide students about good research practices, from the projects execution to the results communication and publication, stressing the importance of research data adequate registration.
Professors Home time Lattes
DENISE CANTARELLI MACHADO 26 years and 11 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Required
Biochemical and Molecular Pharmacology Doctorate Required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Required
Medical Practice Doctorate Required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Required
Neurosciences Doctorate Required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Required
Surgical Practice Doctorate Required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Interdisciplinar Seminar: research, theory and practice
COD Workload Description
1937R-01 15 The discipline comprises presentations of scientific seminars by researchers (with doctoral degrees) in the various basic and applied areas of Health Sciences, with an emphasis on Medicine. After the presentation of the theme, a period of discussion with the speaker and with the participation of the students follows. The aims of the discipline are: ▪ Provide students with contact with the various lines of research covering Medicine and related sciences, thus promoting the integration of knowledge; ▪ Provide students with the opportunity to learn about different areas of scientific research of relevance within Medicine and related sciences through the presentation of seminars by researchers (with doctoral degrees) from renowned local, national and international teaching/research institutions; ▪ Develop critical thinking skills and participate in scientific discussions. The seminars will be shared with the weekly cycle of lectures “Inscer Scientific Meetings”, which take place on Wednesdays, from 12:00 to 13:00. Due to the pandemic, the seminars follow a hybrid model, with the speaker being able to choose to do it in person or remotely. Students can watch via ZOOM or be present at the INSCER amphitheater, with an audience of up to 200 people. The lectures are recorded and made available on InsCer's YouTube channel.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Laboratory Methods Applied to Research
COD Workload Description
7331B-02 30 This course will be concerned with the study of the main laboratory techniques, as their principles of operation, limitations, interfering factors and application in research will be looked at.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Medical Research Methodology
COD Workload Description
33301-02 30 To follow are the topics this course will address: Scientific method elements; Fundamentals of planning of epidemiological research; The functioning of epidemiological research; How to choose the research topic and hypothesis; Support to research: essential elements and abilities for conducting research; The most common research designs; Selecting the subjects and working on measurement; Fundamentals of Biostatistics; Calculating the sample size; Questionnaires, collection instruments and database; Implementing the study: most common perspectives; Analyzing the data, presenting results and designing the final report.
Professors Home time Lattes
MARIO BERNARDES WAGNER 23 years and 4 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Required
Biochemical and Molecular Pharmacology Doctorate Required
Medical Practice Master's Required
Medical Practice Doctorate Required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Required
Neurosciences Doctorate Required
Surgical Practice Master's Required
Surgical Practice Doctorate Required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Molecular Bases of Embryonic Neurogenesis and Neuroplasticity
COD Workload Description
1931B-02 30 The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The brain's ability to change its connections and behaviors in response to new information, stimulation, development, damage or dysfunction is presented as a new adaptive tool called neuroplasticity. Although neural networks exhibit modularity and perform specific functions, they also have the ability to deviate from their usual functions and reorganize. The discipline Molecular Bases of Embryonic Neurogenesis and Neuroplasticity presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Molecular Medicine
COD Workload Description
33341-02 30 The development of the recombinant DNA technology, in progress since the 1970s, has made it possible for us to understand the molecular basis of the cell genome. This has led to a series of phenomena connected to replication, transcription and translation of informational cells, leading the way for a better understanding of cellular operation in normal and pathological situations. On the other hand, such developments have allowed for new laboratory methods for the diagnosis of several pathologies, many of which are completely unknown. As for example, we can mention the development of new drugs for the rational treatment of a series of diseases. The course on Molecular Medicine to be delivered by students from the Graduate Program in Internal Medicine and Health Sciences of the School of Medicine of PUCRS is intended to be a follow-up to the basic courses taught during the undergraduate program in Medicine, such as: microbiology, immunology, genetics and biochemistry, thus introducing new concepts that have emerged over the latest decades as a consequence to the quick development and application of such technology in health care. New developments in areas such as DNA vaccines and gene therapy will be addressed. The course is intended to provide students with the basic insights into the area of molecular biology and biotechnology so that they can assess the articles available in scientific literature related to their areas of interest, with a more critical view on the topics.
Professors Home time Lattes
DENISE CANTARELLI MACHADO 26 years and 11 months Link
DANIEL RODRIGO MARINOWIC 5 years and 5 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Nephrology Research Development and Instruction II
COD Workload Description
33345-02 30 The development of researchers and professors calls for a complete mastery of the scientific method and development of scientific investigation, along with ethically correct attitude. This course will become a useful tool for student development on the scientific method and will be delivered as follows: Presentation and discussion of projects and conduction of research, revision of key publications in the literature, group seminars in nephrology, development of methods and techniques, evaluation of congress publications and topics, auditing of research projects by professors and other guest professors from other areas of concentration (Evaluating Committee).
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Required
Nephrology Doctorate Required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neurobiology of Epilepsies
COD Workload Description
33332-02 30 Research on experimental and clinical epilepsy has allowed advancements in terms of brain functions. So, the study of basic aspects on the function of the nervous system and on the methods of functional investigation of the neurobiology of epilepsies is important.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neurobiology of Human Behavior
COD Workload Description
7333A-02 30 Interest in neurobiology of behavior has grown exponentially as is the availability of methods to study brain operation in vivo. We are more and more interested in the biological determinants that guide our feelings and actions in the world. Neurosciences is an area that seeks to foster an understanding of these processes with an ultimate goal of advancing the prevention and treatment of mental illnesses. Overall, this course seeks to address the aspects that underlie human behavior and emotions.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neurobiology of Stress
COD Workload Description
19347-02 30 Explore the concepts of stress, health and disease, with a particular focus on historical and current literature. It will address multiple dimensions in the study of stress: genetics, epigenetics, molecular, cellular, physiological and cognitive, especially in the context of immunoendocrine and neuroscientific research. Study of the individual response to stress, as genetic and environmental factors play a role, as it translates into physiological and mental conditions and pathological or health conditions.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neuroepigenetics
COD Workload Description
1933G-02 30 Basic and applied research in relation to epigenetic and molecular aspects of cognition and mental disorders.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neuroimaging of Human Cognition
COD Workload Description
63405-02 30 This course will look at the methods of functional neuroimaging, new techniques for the analysis of neuroimaging and the neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Linguistics Master's Not required
Linguistics Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Linguistic Theory and Analysis Addresses the descriptions of the formal, cognitive and communicative aspects of language at the syntactic-semantic and pragmatic interfaces; formal analyses of the phonological aspects of Portuguese and comparative studies of phonological systems and subsystems.
Linguistic-literary principles of language Which addresses the study of meaning in literary and non-literary texts. It involves the theoretical study of the broader field in which the three areas are included – language – and brings together projects related to contemporary society, including those aimed at teaching. This common line promotes interdisciplinary studies, which bring positive results to the area of Letters.
Language Theories and Use Addresses verbal language based on the relationship between theoretical and empirical perspectives on linguistic structure regarding text and discourse, child language acquisition, and linguistic variation.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Neuroimmunology
COD Workload Description
7331C-02 30 This course will address the immunological mechanisms involved in inflammatory diseases of the central nervous system (CNS) and the peripheral one. Immune-mediated diseases such as multiple sclerosis, neuromyelitis optica, immune-mediate encephalitis, Guillain-Barré syndrome and neuroimmunological complications from viral infections will be addressed. Classes will include a discussion forum on the complex interaction between the immune and nervous systems rather than mere presentation of the physiopathologies of these diseases. Students will be encouraged to have a critical view on the scientific literature and reflect upon the possible basic and clinical research on these diseases.
Professors Home time Lattes
DOUGLAS KAZUTOSHI SATO 8 years and 4 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Obesity and Metabolic Syndrome
COD Workload Description
33336-02 30 This course is intended to provide a comprehensive view of these diseases including their historical and epidemiological aspects, public health and national and international economy, ethiopathogenesis, diagnosis, clinical and surgical therapeutic management, prevention and research in their several fields of operation at the present moment and their perspectives.
Professors Home time Lattes
CLAUDIO CORA MOTTIN 43 years and 3 months Link
ALEXANDRE VONTOBEL PADOIN 11 years and 11 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Obesity and Metabolic Syndrome: a multi-disciplinary view
COD Workload Description
63337-02 30 The course is intended to provide students with a global view on the multidisciplinary treatment of morbid obesity patients, involving the joint actions carried out by surgeons, clinicians, nutritionists, psychiatrists, psychologists, social workers, nurses and physiotherapists.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Oncology Seminars
COD Workload Description
1932E-02 30 Over 15 encounters, relevant scientific papers (published in the previous 12 months) on the subject of the seminar will be presented and discussed. Activities will involve preparation of an article for presentation, discussion and critical evaluation. Dependent on the topic of selected articles, other PPG teachers may be invited to participate in the discussion of the article.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Pathophysiology of Proteolysis
COD Workload Description
1935N-02 30 Processes mediated by limited proteolysis have important pathophysiological repercussions. The study of proteases and the processes in which they operate has a multidisciplinary character, involving knowledge in biochemistry, biophysics and physiology of the systems involved. The course will address fundamental concepts about proteolytic enzymes and their inhibitors, and special emphasis will be given to pathologies involving limited proteolysis, according to the following topics: i. Proteolytic enzymes: general aspects ii. Protease inhibitors: classes iii. Blood clotting and fibrinolysis iv. Complement system v. Prohormone convertases and oligopeptidases saw. Beta-convertase pathway and formation of amyloid peptides vii. Caspases and apoptosis viii. Proteasome and ubiquitination ix. Proteolysis in embryonic development
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Pharmacology of Inflammation
COD Workload Description
23394-02 30 This course is intended to address several aspects related to the pharmacology of inflammation, namely: biochemical and molecular aspects of inflammatory events, with emphasis on pharmacological modulation. The main vascular and cellular alterations in response to different stimuli will be addressed. To follow are some topics of interest: (1) study of inflammatory response mediators, including those derived from mastocytes (histamine and serotonin), lipid mediators (prostanoids and leukotrienes), peptidic mediators (bradikinin and neurokinin), cytocines and growth factors, chemotactic factors, complement system mediators, nitric oxide, among others; (2) components of the resolution phase of inflammation, involving endogenous mediators related to the re-establishment of homeostasis and tissue repair; (3) main groups of cells involved in several phases of inflammation and their connection to immune response; (4) main receptors and signaling routes, as well as the components of intracellular transduction systems; (5) inflammation associated with infection and systemic inflammatory response; (6) correlation between inflammation and cancer; (7) regulatory aspects of the transcription of molecules implied in inflammatory response; (8) study of mechanisms of action of main drugs used in the treatment of inflammation; (9) chronic inflammatory diseases.
Professors Home time Lattes
MARIA MARTHA CAMPOS 18 years and 4 months Link
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus.
Psychosocial Processes: Practices and contexts This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge.
Cognition, brain and behavior This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience.
Well-being, health and quality of life This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Pharmacotherapy of Neurological and Psychiatric Disorders
COD Workload Description
1932A-01 15 Neuropharmacology is the study of the effect of drugs on the brain. The seminars explore the concepts and current research in cognitive neuroscience, including perception, brain structure and organization, cognition, memory and the functional basis of certain human neurological and psychiatric illnesses. (e.g. schizophrenia, depression and Narcolepsy). The purpose of this course is to provide students with an opportunity to acquire the theoretical and applied knowledge of neuropharmacology that will enable them to proceed into developing a career in neuropharmacology either in an academic institution, a research institute or in the industrial/business sector.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Pediatrics Master's Not required
Pediatrics Doctorate Not required
Pharmaceutical Biotechnology Professional Master's Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Poisons and Natural Toxins: from molecules to clinical cases.
COD Workload Description
63444-02 30 The study of animal poisons (reptiles, anthropoides and mollusks) and natural toxins (microbial ones and plants) has a multidisciplinary nature, and will address the structural aspects of toxic molecules, their mechanisms of action and how they manifest in patients, up to the treatment of clinical cases. Another aspect of the study of these molecules is the design of new toxin-based therapeutic drugs, based on the understanding of their interactions with cell targets. In this context, this course is intended to address the main groups of proteins and toxic peptides found in animal poisons, as well as toxins produced by plants and bacteria. The molecular aspects and mechanisms of action of the main groups of protein and peptide proteins will be addressed, as well as a discussion of the clinical cases representing each type of poison/toxin. To follow are the groups of toxins to be addressed: 1. phospholipases of poisons of serpents and anthropoides: hemotoxins, neurotoxins and mycotoxins; 2. toxins interfering with G proteins: ADP-riboses (cholera and pertussis toxins) shiga toxins; 3. clostridial toxins and anthrax zync - metalloproteinase (tetanus and botulinum toxins); 4. toxins interfering in protein synthesis: RNA N-glucosidases (ricin and abrin) ADP-riboses (diphtheria toxin, pseudomonas and exotoxin A); 5. toxins affecting ion channels, serpents (A-bungatoxin, three-fingers, phospholipases) arthropodes (tityustoxin, A-latrotoxin, charabtoxin, etc.) mollusks (conotoxins).
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Practice in Medical Research Software
COD Workload Description
63348-04 60 Knowing how to use computer tools is fundamental for conducting research in health. This course is intended to explore, in a practical way, important software for medical research. The focus will be on online resources, spreadsheets, graphic programs, statistical programs, word processors, and bibliographic reference management.
No offer for current semester
Concentration area Type Required
Biochemical and Molecular Pharmacology Master's Not required
Biochemical and Molecular Pharmacology Doctorate Not required
Biomedical Gerontology Master's Not required
Biomedical Gerontology Doctorate Not required
CTBMF Master's Not required
CTBMF Doctorate Not required
Cellular and Molecular Biology Master's Not required
Cellular and Molecular Biology Doctorate Not required
Clinical Psychology Master's Not required
Clinical Psychology Doctorate Not required
Clinical Stomatology Master's Not required
Clinical Stomatology Doctorate Not required
Dental Materials Master's Not required
Dental Materials Doctorate Not required
Dental Prosthetics Master's Not required
Dental Prosthetics Doctorate Not required
Endodontics Master's Not required
Endodontics Doctorate Not required
Human Cognition Master's Not required
Human Cognition Doctorate Not required
Medical Practice Master's Not required
Medical Practice Doctorate Not required
Nephrology Master's Not required
Nephrology Doctorate Not required
Neurosciences Master's Not required
Neurosciences Doctorate Not required
Orthodontics and Facial Orthopedics Master's Not required
Orthodontics and Facial Orthopedics Doctorate Not required
Pediatrics Master's Not required
Pediatrics Inter-institutional doctorate degree Not required
Pediatrics Doctorate Not required
Psychology Doctorate Not required
Restorative Dentistry Master's Not required
Restorative Dentistry Doctorate Not required
Social Psychology Master's Not required
Social Psychology Doctorate Not required
Surgical Practice Master's Not required
Surgical Practice Doctorate Not required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Training and Faculty Development in Health
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Technological Innovations in the Health Area Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies
Artificial Intelligence in Healthcare Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct.
Assessment and psychological interventions in mental health This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at unders