Courses

Applied Pharmacology
COD Workload Description
13599-02 30 This course will focus on the study of the basic concepts of pharmacology, with particular emphasis on the biochemical and molecular aspects that have an influence on the actions of drugs and biopharmaceuticals. It will also deal with the aspects of pharmacodynamics and pharmacokinetics at the basic and applied level. Lastly, it will look at the animal models used for the development of biopharmaceuticals.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Biotechnological Processes
COD Workload Description
23501-02 30 To follow is a list of topics this course will address: Introduction. Concepts of Phase equilibrium and Mass transfer phenomena. Selection of separation, extraction and purification processes. Separation, extraction and purification processes Volatile and non-volatile extracts. Applications of phytoextracts
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Disperse Systems Technology
COD Workload Description
23548-02 30 This course will look at disperse systems technology, emulsions, nanoemulsions, microemulsions, solid lipid nanoparticles. As well as this, it will look at the methods of preparation, characterization and study of stability of disperse particles
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Drug Design and Molecular Modeling
COD Workload Description
13592-02 30 To follow is a list of topics the course will address: Historical introduction to the planning of drugs and molecular modeling. Computational approaches to pharmaceutical problems. Genome database. Receptor databases and target proteins of pharmaceutical interest. Structure and function of proteins/receptors. Visualization and manipulation of 3D structures of biological macromolecules. Molecular modeling of 3D structures of proteins/receptors. Databases of small drug molecules. Descriptors and molecular filters. Intermolecular interactions. Molecular docking. Ligand-based virtual screening. Applications of drug design and molecular modeling
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Good Practices in Biotechnological Production
COD Workload Description
13591-02 30 This course will address the good practices of production and validation of processes for products of biotechnological origin. It will also address the critical points of control. Lastly, it will touch on the legal aspects on production and biosafety.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Immunochemistry and immunodiagnosis
COD Workload Description
13593-02 30 This course will look at the study of chemical properties of the immunology. It will also look at the chemical study of antigens, antibodies and their reactions. It will touch on the physical, chemical and biological interactions of antigens, antibodies and haptens. Lastly, students will be able to design assays, marking techniques, primary care tests - Quick Tests - validations - product registration.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Integration Seminar
COD Workload Description
13597-02 30 This course will consist of the delivery of scientific seminars by researchers, professors or graduate students in the several areas of Pharmaceutical Biotechnology, with emphasis on research and assessment of molecular targets and development and assessment of biotechnological products. After the topics are delivered, graduate students will be expected to join discussions on them.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Molecular Biology and Genetic Engineering
COD Workload Description
23551-02 30 This course, of theory and practicum nature, is intended to provide training in the abilities and applications commonly employed in biotechnology and molecular biology laboratories. Some of the topics it addresses are the foundations of recombinant DNA technology and its applications in the development of biopharmaceuticals, new drugs to fight diseases such as cancer, autoimmune diseases and errors of metabolism; The most common techniques employed in genetic engineering and their applications, especially those related to Biotechnology; Methods that employ biotechnology and genetic manipulation tools, such as cloning, transgenesis and cell therapy; The impacts of genetic engineering on society; As for laboratory practice, students will be able to employ the experimental techniques and abilities commonly used in biotechnology, molecular biology and cell culture laboratories.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Nanostructured Materials
COD Workload Description
23500-03 45 To follow is a list of topics this course will address: Nanocomposites. Nanotechnology applied to energy. Biomedical applications of nanotechnology. Molecular recognition in a nanometric scale. Nanotechnology and the environment;
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Pharmaceutical Biotechnology
COD Workload Description
13590-04 60 To follow is a list of topics this course will address: The background of biotechnology in the historical and scientific scenario. The importance of biotechnology for the development of processes and its reflections on human health. An approach to different biotechnological processes and their applications. A provision of deeper insights into pharmaceutical biotechnology, with emphasis on biopharmaceuticals and molecular targets (Proteins and DNA) for the development of drugs.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Pharmaceutical Technology
COD Workload Description
23502-02 30 To follow is a list of topics this course will address: Pre-formulation of dosage forms. Biopharmacy. Pharmaceutical adjuvants. Technology of different dosage forms. Future dosage forms.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Pharmacotherapy of Neurological and Psychiatric Disorders
COD Workload Description
1932A-01 15 Neuropharmacology is the study of the effect of drugs on the brain. The seminars explore the concepts and current research in cognitive neuroscience, including perception, brain structure and organization, cognition, memory and the functional basis of certain human neurological and psychiatric illnesses. (e.g. schizophrenia, depression and Narcolepsy). The purpose of this course is to provide students with an opportunity to acquire the theoretical and applied knowledge of neuropharmacology that will enable them to proceed into developing a career in neuropharmacology either in an academic institution, a research institute or in the industrial/business sector.
Professors Home time Lattes
JOCIANE DE CARVALHO MYSKIW 7 years and 8 months Link
Concentration area Type Obligatoriness
Biochemical and Molecular Pharmacology Master's Don't Required
Biochemical and Molecular Pharmacology Doctorate Don't Required
Biomedical Gerontology Master's Don't Required
Biomedical Gerontology Doctorate Don't Required
Cellular and Molecular Biology Master's Don't Required
Cellular and Molecular Biology Doctorate Don't Required
Medical Practice Master's Don't Required
Medical Practice Doctorate Don't Required
Nephrology Master's Don't Required
Nephrology Doctorate Don't Required
Neurosciences Master's Don't Required
Neurosciences Doctorate Don't Required
Pediatrics Master's Don't Required
Pediatrics Doctorate Don't Required
Pharmaceutical Biotechnology Professional Master's Don't Required
Surgical Practice Master's Don't Required
Surgical Practice Doctorate Don't Required
Research line Description
Evaluation of mechanisms involved in inflammatory and nociceptive alterations This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations
Drug Development This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases.
Preclinical neuropharmacology This line of research is concerned with Pre-Clinical Neuropharmacology.
Evaluation of pharmacological targets in cancer treatment This line of research is concerned with the evaluation of pharmacological targets in cancer treatment.
Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases Study of the neurochemical roots and pharmacological targets in neurological diseases.
Biological Aspects of Aging This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo).
Clinical and Emotional Aspects of Aging This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition.
Social-cultural, Demographic and Bioethical Aspects of Aging This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging.
Aging and Public Health This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life.
Cell Structure and Metabolism To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action.
Cellular and Molecular Immunology To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts.
Cellular and Molecular Characterization in Microbiology and Parasitology To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents.
Genetics, Genomics and Bioinformatics To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics.
Cellular and Molecular Neurobiology To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels.
Molecular Biology in the Drug/Target Interaction To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer.
Respiratory Diseases / Exhaled nitric oxide and others markers of inflammation This line of research is intended to assess the role of expired nitric oxide as an inflammation marker.
Molecular Biology, immunology and stem cell This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering.
Cardiology/Risk Factors and genetics factors in cardiovascular diseases This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases.
Cardiology/Cellular therapy This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction.
Respiratory Diseases / Smoking and smoking-related diseases This line of research will address the determining factors of success/failure in smoking cessation; it will assess the role of genetics in the experimentation, maintenance and cessation of smoking; it will test the efficacy of different therapies.
Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population.
Clinical Epidemiology This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population.
Functional and Molecular Image of the Body Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely.
Epidemiology and Environmental Health This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population.
Training and Development for Teachers in Health Sciences This line of research will enable the production of scientific and technological research and the provision of Master's and Doctoral degrees as well as the conduction of Postdoc research in the area of Health Care Education.
Extra-renal dialysis and transplatation This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants.
Clinical nephrology and arterial hypertension This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases.
Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases.
Mechanisms of memory consolidation This line of research will look at the role of the central histaminergic system in the basolateral amygdala and in the hippocampus in the consolidation of aversive and non-aversive memory. It will also look at the influence of the treatment relying on a histidine decarboxylase inhibitor.
Developmental neurology This line of research will deal with the ontogenesis and bioelectrogenesis of the Central Nervous System (clinical aspects and animal model), sleep studies and its disorders through the assessment of clinical and neurophysiological characteristics, thus laying the foundations for the understanding of sleep medicine in childhood, and the normal and abnormal development in early childhood.
Neurology/ stem cells This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries.
Cholinergic versus non-cholinergic components of memory The purpose of this line of research is to determine the components of memory deficits observable in transgenic rats incapable of expressing the fast transporter of hippocampal acetylcholine in different degrees. This can be applied to the treatment of the Alzheimer's disease with pro-collinergic drugs among others.
Behavioral neurology and neuropsychiatry This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases.
Cognitive brain imaging This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning).
Synaptic tagging of extinction The generation of weak LTP in a dendrite of pyramidal cells of the hippocampus can increase its potential by the LTP produced in another distant dendrite. This is called synaptic tagging and is due to the tagging of the first synapsis (tag) by a local protein which attracts another generated by the second synapsis (capture).
Neurotoxic activity of ureases and derived peptides This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts.
Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions.
Childhood epilepsy This line of research will address epilepsy in childhood.
Epilepsy This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain.
Asthma: epidemiology, genetics and the study of basic mechanisms Epidemiology of asthma in different populations.
Respiratory Failure Etiopathogenesis, epidemiology, diagnosis and management of high impact respiratory infections in the pediatric population.
Stem cells and neurodegenerative diseases To assess the possibility of recovery of central and peripheral neurological lesions resulting from neurodegenerative diseases with somatic stem cells, as well as to study the mechanisms of structural and functional recovery of lesions.
Diagnostic and Therapeutic Interventions in Newborn Infants It addresses interventions in neonatal respiratory diseases, infectious diseases and nutrition disorders.
Pediatric Clinical and Experimental Epilesy Study of epileptic syndromes that begin during childhood including etiology, pathophysiology, characterization of specific syndromes, complementary investigation, comorbidities, treatment (clinical and surgical) and evaluation / development of new antiepileptic drugs. The experimental approach uses an in vitro and in vivo model of electrophysiology and immunohistochemistry, as well as a model to verify the effects of early seizures in the developing CNS.
Clinical Epidemiology applied to child health issues Study the validity of signs, symptoms and screening and diagnostic tests; and epidemiological indicators of childhood diseases and disorders, such as incidence, prevalence and mortality, relating them to etiological and prognostic factors.
Prematurity: impact in lung development and immune response To address pulmonary growth and development, focusing on the direct and indirect effects of prematurity on the lung.
Epigenetic and Molecular Mechanisms of Developmental Stress To investigate epigenetic and molecular mechanisms related to neurocognitive and behavioral development after exposure to early stress.
Cystic Fibrosis: epidemiology, genetics and therapeutics Epidemiology, genetic diagnosis and therapy of childhood lung diseases.
Tumor Immunology To study tumor immunology
Functional evaluation and rehabilitation in chronic respiratory diseases Research in the area of ​​functional assessment and rehabilitation of patients with chronic diseases, such as cystic fibrosis and asthma. It focuses on aspects such as physical activity and physical inactivity, pulmonary function, musculoskeletal development, obesity and quality of life.
Behavioral and Developmental Neurology Study of ontogenesis and bioelectrogenesis of the Central Nervous System. It evaluates, through polysomnography, the physiological changes and gestational age dependent and the influence of neonatal neurological disorders in the process of organization of brain electrical activity. It evaluates the neurological follow-up of premature newborns, considering the effects of prematurity on neuropsychomotor development. It evaluates the follow-up of term neonates with congenital infectious pathologies and hypoxic-ischemic encephalopathy. Includes study of sleep and its disorders through the evaluation of clinical and neurophysiological characteristics forming the basis for understanding sleep medicine in childhood.
Immune responses to respiratory viral infections To analyze immune response to viral respiratory infections.
Stress and development It studies the mechanisms and development of possible therapies to prevent and / or treat the effects of early life interventions and their repercussions on the organism's development. It uses experimental research resources to study stress, inflammation, respiratory diseases, systems development, physical activity and their relationships with the life-long effects of perinatal changes.
Evaluation of the impact of interventions in early stages of development on neurochemical mechanisms and reflexes on behavior in juvenile and adult phase using animal models.
Research on the role of inflammation and the immune system in neurological diseases. Investigation of genetic and environmental factors. Development of experimental models, research on biomarkers, neurodegenerative processes, cognitive assessment and neuroimaging (magnetic resonance imaging and nuclear medicine) in diseases such as multiple sclerosis, optic neuromyelitis, anti-MOG-associated disease, acute disseminated encephalomyelitis (ADEM) and autoimmune encephalitis.
The line is designed to study all aspects related to therapy, prognosis and humanization in Pediatric Intensive Care and Emergency Units. It also includes study of aspects that refer to the professionals and management processes involved within these units.
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Cell Terapy (Clinicals and experimental models, Regeneration and Tissue engineering, stem cells) This line of research will look at clinical and experimental models focused on the development of stem cells therapies, nervous regeneration and the use of stem cells in surgeries.
Obesity and Metabolic Syndrome This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies.
Peripheral nerve (Clinical and experimental models, nerve regeneration, growth factors, stem cellls) Tissue Engineering (TE) is concerned with the study of new forms of tissue production to be used in reconstructive surgeries. It covers all methods and efforts made in order to create or induce the formation of tissues in a specific location.
Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community.
Videolaparoscopic Surgery This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques.
Pre-Clinical and Clinical Assays
COD Workload Description
13598-02 30 This course will address the pharmacological and toxicological guidelines for the conduction of non-clinical assays in products of biotechnological origin. It will cover approaches of national and international non-clinical and clinical study methods of bioactive compounds. Lastly, it will look at the legislation regulating both non-clinical and clinical assays.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Project Design and Management.
COD Workload Description
13595-02 30 To follow is a list of topics the course will address: Methodological planning and organization for the development of products and processes. Project management and planning in the business scenario. Scope management. Time management. Risk management. Quality management. Cost management. Team management. Communication management. Project planning, monitoring, execution and closing.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Quality Control of Pharmaceutical Products
COD Workload Description
13596-02 30 To follow is a list of topics the course will address: Quality control of pharmaceutical products and cosmetics for human/animal use. Qualitative and quantitative determination of active ingredients. The employment of analytical methodologies for measuring physical-chemical characteristics. Nuclear Magnetic Resonance, Mass Spectrometry, HPLD and Infra-red. The employment of statistical methods applied to bioassays.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Radiopharmaceuticals
COD Workload Description
13594-02 30 To follow is a list of topics this course will address: Introduction to general concepts applied to the use of radiopharmaceuticals for research and clinical diagnosis. Types of radiopharmaceuticals. Production and good practices of fabrication in radiopharmacy. Influential factors in the development of new radiopharmaceuticals. Methods of measurement using short half-life radioisotopes. Radioisotopes originating from reactors, cyclotrons and generators.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.
Vaccine Design and Production
COD Workload Description
23523-02 30 The course is intended to provide a comprehensive view of the principles of vaccination, general recommendations, the side effects of available vaccines and information on preventable diseases. It will look at the study of widely employed technologies for the production of vaccines available in the market and the new technologies studied for the production of vaccines to be developed.
No offer for current semester
Concentration area Type Obligatoriness
Pharmaceutical Biotechnology Professional Master's Don't Required
Research line Description
Research and evaluation of molecular targets This line of research aims at the identification, characterization and validation of macromolecules as possible targets for the development of drugs and diagnostic tests focused on infectious, chronic degenerative, and neglected diseases. In these processes, bioinformatics tools, such as the techniques of computational molecular biophysics, will be employed. The synthesis of new chemical compounds capable of interacting with macromolecular targets will also be approached. In this line, pharmacological and toxicological studies of molecules are also developed.
Development and evaluation of biotechnology-based products This line of research involves studying the process of development of biotechnology-based products, focusing on biopharmaceuticals. Exploring the development of in vitro and in vivo diagnostic systems and their applications. Developing biological research in hypergravity, and also evaluating and characterizing nanostructured pharmaceutical materials and new radiopharmaceuticals applied in nuclear medicine.